There is no such thing as the nemesis of proctitis is mesalazine, mesalazine can be used in the treatment of ulcerative colitis and other diseases, and should be used in accordance with medical advice. Proctitis is an inflammation of the lining of the rectum, which can manifest as abdominal pain, urgency, and blood in the stool. It can be caused by inflammatory bowel disease, radiation therapy, infections, the use of antibiotics, and foreign body injury. Mesalazine can act on the intestinal mucosa and submucosal tissues to play an anti-inflammatory role. It is used in the treatment of acute exacerbation of ulcerative colitis, as well as maintenance therapy to prevent the recurrence of ulcerative colitis, and also used in the treatment of acute exacerbation of Crohn’s disease. Therefore, Mesalazine is not a drug for the treatment of proctitis, and there is no such thing as the nemesis of proctitis being Mesalazine. Mesalazine adverse reactions can be seen as headache, dizziness, flatulence, abdominal pain, diarrhea, nausea, vomiting and so on. The drug is contraindicated in people who are allergic to Mesalazine, renal dysfunction, severe hepatic dysfunction, gastric or duodenal ulcers, and people with bleeding-prone constitution. The drug should be used rationally under the guidance of a doctor.