The appearance of blood blisters on the body is considered to be caused by a variety of conditions. Consider herpes simplex, the early manifestation of herpes simplex is small blisters distributed in local clusters, and later may manifest as bloody blisters due to increased local bloody secretions, the pathogenesis is related to herpes simplex virus infection, clinical antiviral drugs can be selected for treatment, including acyclovir and famciclovir. Consider herpes zoster, whose lesions are characterized by clustered distribution of blisters and papules with a red base and unilateral distribution, usually not exceeding the midline, and whose pathogenesis is related to immune deficiency, and for which antiviral drugs, such as valacyclovir, and nerve-nourishing drugs such as methylcobalamin, can be chosen. Consider rare skin diseases such as erythema multiforme, aspergillosis, and aspergillosis-like.