Myeloma can be diagnosed on the basis of clinical presentation and relevant tests (e.g. bone marrow examination). Myeloma is a malignant tumor originating from plasma cells in bone marrow. Multiple ones are called multiple myeloma or myelomatosis, and solitary myeloma is also called isolated myeloma. 1. Clinical manifestations: pain is the main symptom, which can be aggravated by walking, activity and exercise. It may also manifest as anemia, skin petechiae, bleeding spots, and even corresponding symptoms such as limb paralysis, lethargy, proteinuria, hyperuricemia and so on due to the influence of nerves and kidneys. 2.Related examination (1) Bone marrow examination: the number of plasma cells is abnormally increased, and they are primitive or naive plasma cells with abnormal morphology. The cell morphology varies in size, the nucleus can be seen in the nucleus 1 to 4, and binucleated or multinucleated plasma cells can be seen. (2) Routine blood tests: mostly normocytic, normochromic anemia, most of the platelets are normal, or can be low. (3) Imaging examination: Because myeloma has bone changes, imaging bone changes is also an important indicator for diagnosing myeloma, such as CT, MRI, PET-CT, etc. If the above symptoms appear, it is recommended to go to the hospital in time for early and regular treatment.