Syphilis that is negative for two months still has the possibility of turning positive, so early syphilis needs to follow up regularly for 2 to 3 years, and advanced syphilis needs to follow up for 3 years or more. Incomplete treatment of syphilis may lead to serologic recurrence, and if the antibody titer rises more than four-fold on retest, it means that the treatment has failed or that reinfection has led to a positive result. If the treatment fails, re-treatment or increase the dosage or prolong the course of treatment is needed according to the specific situation. In order to avoid cross-infection, it is recommended that the partner undergoes the relevant tests and treatments. Early, adequate and standardized medication (preferred penicillin, ceftriaxone for penicillin allergy) and avoidance of risky sexual behaviors can effectively reduce the chances of positive conversion. After treatment, follow up for antibody titer changes as prescribed by the doctor.