Leukemia knee pain and general knee pain can be distinguished from each other in terms of pathogenesis, pain characteristics and symptoms, and treatment effects. 1. Causes: Leukemia knee pain is caused by a large number of leukemia cells infiltrating the bones; while general knee pain may be caused by knee joint swelling or irritation of nerve endings due to knee trauma, synovitis, rheumatoid arthritis and so on. 2. Characteristics and symptoms of pain: leukemia knee pain is usually hidden pain or soreness, but if bone marrow necrosis occurs, there will be severe pain in the knee. In addition, it is often accompanied by fever, anemia and bleeding and other symptoms; general knee pain manifested as knee pain, swelling, may have popping and limitation in joint activities, pain aggravated when going up and down the stairs, walking limp and so on. 3. Treatment effect: leukemia knee pain taking pain medication such as ibuprofen tablets, the effect is very poor; while the general knee pain in the use of the above pain medication or topical swelling medication, the effect is generally better. Therefore, if there is an unknown cause of knee pain, and the effect of painkillers is very poor, it is recommended to improve the relevant examinations in a timely manner, to exclude the possibility of leukemia, so as to achieve early diagnosis and early treatment, the use of drugs under the guidance of a physician.