Hyperthermia is the combination of heat therapy and chemotherapy means, scientifically and rationally formulating clinical treatment plans, bringing into play the synergistic effect of heat therapy and chemotherapy to further improve the therapeutic efficacy and survival rate, reduce patients’ pain and improve the quality of life. Animal experiments and clinical studies have shown that the efficacy of hyperthermia combined with chemotherapeutic drugs in the treatment of malignant tumors is significantly improved. The mechanisms of hyperthermia in the treatment of tumors are as follows: (1) Hyperthermia enhances the cytotoxicity of certain chemotherapeutic drugs (e.g. platinum, anthracyclines, etc.). (2) Heating changes the pharmacokinetics of chemical drugs and increases the local blood flow to the tumor, thus increasing the uptake of drugs in the tumor; moreover, the concentration of drugs in the tumor is higher when heating is administered simultaneously with chemotherapy than when chemotherapy is administered after heating. (3) Heating inhibits DNA damage repair mediated by DNA polymerase and denatures certain proteins, so heating may reverse the multidrug resistance of some chemotherapeutic drugs. (4) Inducing more tumor cells to apoptosis. Heat therapy tends to reach higher temperature in the central part of tumor tissue, and heat therapy is more likely to induce apoptosis in the acidic environment of the central part. In addition, heat therapy can also induce the body’s anti-tumor immunity, mainly including the enhancement of NK cells, T lymphocytes and macrophages immune effect. The American BSD2000 deep tumor phased-array thermal therapy system belongs to regional thermal therapy, and its technology represents the advanced level of tumor thermal therapy today. In recent years, we have conducted in-depth researches on the combination of heat therapy and chemotherapy in the treatment of advanced malignant tumors, which confirmed that this treatment has a high safety level and no serious adverse reactions occurred; secondly, patients showed the reduction or control of tumor lesions, improvement of clinical symptoms and quality of life through heat chemotherapy, suggesting that this therapy has a good application prospect in the clinic. Again, for some patients who are difficult to tolerate the toxic side effects of chemotherapy, the dosage of chemotherapy drugs can be appropriately reduced without affecting the therapeutic efficacy.