Thermochemotherapy, which is the combination of chemotherapy and thermotherapy means, scientifically and rationally formulates clinical treatment plans, with a view to improving treatment efficacy while minimizing drug dosage, in order to obtain maximum benefits, improve patients’ survival rate, reduce pain and improve quality of life. At present, there are two main ways of thermochemotherapy, one is chemotherapy before thermotherapy and the other is chemotherapy during thermotherapy. Thermochemotherapy can enhance the sensitivity of tumors to chemotherapy: thermotherapy enhances the fluidity and permeability of cell membranes, which makes it easier for chemotherapy drugs to enter into cancer cells and kill them. Meanwhile, heat therapy can reduce and reverse the resistance of cancer cells to drugs, making cancer cells easier to be killed. Heat therapy can improve the cellular immune function of the body: Clinical studies have confirmed that heat therapy can enhance the anti-tumor immune function of T lymphocytes, natural killer cells and macrophages. Eliminate and relieve cancer pain: A large number of clinical treatment results show that heat therapy can effectively eliminate or relieve cancer-induced pain. Kill metastatic cancer cells: Tumor metastasis is a serious problem faced by most cancer patients. Metastasis is almost always present and active during the occurrence and development of tumors. The incomplete vascular structure of tumors makes it easy for tumor cells to penetrate the vascular wall and enter the blood circulation. Thermochemotherapy can effectively kill metastatic cancer cells in time and improve the long-term survival rate of cancer patients after surgery. Inhibit tumor neovascularization: metastatic cancer cells need new angiogenesis in order to grow into metastatic tumors. Whole-body thermotherapy can significantly inhibit the production of VEGF (vascular growth factor), which promotes blood vessel growth, thus inhibiting cancer recurrence and metastasis.