Elevated direct bilirubin may be caused by biliary tract obstruction, hemolytic disease, liver disease, etc. Elevated direct bilirubin is not harmful to the human body, while the diseases that cause it to be elevated are harmful to the body, such as jaundice, fever, anemia, cirrhosis of the liver, and so on. 1. Obstructive biliary tract diseases: for example, biliary tract stones or biliary tract tumors, which are blocked in the common bile duct or common hepatic duct, resulting in the direct bilirubin produced by the liver can not be excreted to the intestines, thus causing obstructive jaundice and a significant increase in direct bilirubin, which can cause different degrees of jaundice, as well as infections and fever. 2. Hemolytic diseases: for example, hemolytic anemia, due to excessive destruction of red blood cells inside and outside the blood vessels, resulting in excessive production of indirect bilirubin, which will also cause an increase in direct bilirubin, manifested as hemolytic jaundice. This type of disease will lead to anemia, panic, fatigue with jaundice. 3. Liver diseases: For example, when hepatitis and drug-related liver damage occur, due to the destruction of liver cells, their ability to convert and excrete bilirubin decreases, resulting in elevated direct bilirubin. This kind of disease will lead to liver function damage, and in serious cases, liver cirrhosis and hepatic encephalopathy will occur. If you have high direct bilirubin, it is recommended that you go to the hospital as soon as possible for medical consultation and relevant treatment for the cause of the disease, and do not take medication on your own and delay your condition.