Oral and lip herpes is self-healing, if the symptoms are serious, you can take topical medication and oral medication. 1. Topical medication: Acyclovir cream and Penciclovir cream can be used topically to relieve pain, chlorhexidine mouthwash can be used to keep the mouth clean, and Cedroxidin tablets can also be taken. 2. Oral medication: Oral antiviral medication can be taken, acyclovir, valacyclovir, penciclovir, etc. Antipyretic and analgesic medication can also be used to relieve pain or reduce fever, commonly found in ibuprofen, acetaminophen extended-release tablets and so on. Oral and lip herpes is caused by herpes simplex virus infection, there is a certain degree of self-healing, if the patient has pain, fever and other manifestations, we should consult a doctor in a timely manner, in accordance with the doctor’s instructions for the use of medication in sufficient quantities, full course of treatment. Daily attention should be paid to rest, avoid exertion, avoid sharing towels and so on.