Nasal septum perforation is a permanent perforation of the nasal septum caused by trauma or other diseases, and the disease cannot heal itself without standardized treatment. For non-independent septal perforations with a clear cause, the primary disease is treated first. For simple septal perforation, perforation repair is an option. The repair method and material are chosen according to the location and size of the perforation. The main methods include: septal mucoperiosteal reduction suture, mucoperiosteal flap or mucoperiosteal flap transfer suture, free tissue grafting, and silicone rubber sheet placement. After nasal septum perforation surgery, it is necessary to pay attention to long-term follow-up, monitor the change of symptoms, and timely review when headache, nasal congestion and other symptoms occur. It is important to keep the nasal cavity moist on a daily basis, avoid going to dry and dusty places, change bad habits, and avoid picking your nose with your hands.