Lymph nodes in the neck may be caused by inflammation or related to tumors, and anti-inflammatory as well as surgical treatments, chemotherapy and radiotherapy, etc. are needed for treatment. 1. Lymph nodes in the neck should be examined by neck ultrasound. The most common cause may be caused by inflammation, which may be secondary to upper respiratory tract infection or oral infection accompanied by sinusitis. Anti-infective treatment should be given, such as intravenous penicillin or cephalosporin and other drugs. 2. If the lymph node enlargement is caused by malignant tumor, the primary lesion should be further examined. In case of distant metastasis, local lymph node excision biopsy or fine needle aspiration should be performed to determine the pathological type, and surgical treatment as well as combined intravenous chemotherapy or radiotherapy can be chosen for treatment. Due to different causes and different treatment options, patients are advised to go to the hospital immediately for examination and standardized treatment under the guidance of professional doctors to avoid delaying the condition.