Lymphoma bone destruction is to stage 4 lymphoma. Lymphoma stage 1 and 2 are in the early stages of lymphoma. Lymphoma invades the bone marrow, which can lead to bone destruction, and may also invade the lungs, liver, soft tissues, etc. At this time, it belongs to the stage 4 of lymphoma, because of the destruction of bone and tumor invasion of the nerves, the patient manifests pain in the affected area, and may even lead to fracture, activity limitation, movement disorders, and other such uncomfortable symptoms. The prognosis of lymphoma bone destruction is relatively poor, and it can be treated by immunotargeted therapy, chemotherapy, combined with local radiotherapy. People with lymphoma bone destruction should actively seek medical treatment, formulate individualized treatment plans under the guidance of physician’s interview, and follow the standard treatment, patients should not self-medicate to avoid adverse results.