Pain in the middle of the back vertebrae may be caused by strain injury, trauma, spinal lesions, lumbar spine lesions or tumors. 1. Strain: mostly refers to the people who bear weight on the back for a long time, and the pain is caused by the damage of the soft tissues of the back. 2. Trauma: Commonly caused by strains, fractures, impacts, etc., resulting in back pain, redness, swelling, and decreased flexibility in activities. 3. Spinal lesions: including ankylosing spondylitis, spinal arthritis, etc., which manifests as pain in the middle of the backbone, fatigue, and stiffness after sitting for a long time. 4. Lumbar spine lesions: such as lumbar spondylolisthesis, lumbar intervertebral disc stenosis, etc. In addition to back pain, there are lumbar pain, numbness in the legs and feet, and inconvenience in walking. 5. Tumor: mostly seen in bone tumor, due to the pain caused by tumor compression of blood vessels or nerves, local lumps, numbness in the back and so on. There are many other causes of back pain in the middle of the vertebrae, if the symptoms persist or aggravate, it is recommended to go to the hospital as soon as possible, with the help of the doctor to identify the cause of the disease and take targeted treatment.