It is necessary to review hypothyroidism at 28 weeks of pregnancy and to adjust the dosage of medication under medical supervision. Combined hypothyroidism in pregnancy increases the risk of preeclampsia, fetal miscarriage, and congenital defects, etc. After a clear diagnosis, levothyroxine should be given to control the thyrotropin (TSH) level as prescribed by the doctor. As the weeks of pregnancy increase, the fetal need for thyroxine increases, so it is necessary to review thyroid function at 28 weeks of pregnancy to adjust the dose of medication. For pregnant women with combined hypothyroidism, nutritional guidance should be strengthened during pregnancy and intrauterine fetal development should be monitored. Fetal monitoring during pregnancy and labor should also be strengthened in order to be able to detect fetal distress in time. Newborns need to be examined for thyroid function after birth, and when neonatal hypothyroidism is clearly present, treatment should be given as prescribed by the doctor.