There are two general causes of pain between two ribs: first, intercostal nerve pain. The intercostal nerve is a nerve located between the two ribs, when intercostal neuralgia, there will be pain between the two ribs. At this time, you can take oral nutritional nerve drugs, or local closed treatment, often get good results. Second, herpes zoster, herpes zoster will appear in the early stage of the pain in the middle of the two ribs. Shingles is a viral infection that often involves the nerves between the ribs and causes pain. This can be treated with oral pain medication, as well as nerve-nourishing medication, while watching for clusters of blisters around the painful ribs. If there are blisters forming, it is important to visit a dermatologist for further diagnosis and treatment.