Wasting weight and blood in stool may be caused by Crohn’s disease, ulcerative colitis, tumor, etc., and it is necessary to go to the hospital in time to improve the examination and determine the treatment plan. 1. Crohn’s disease: mostly seen in the end of ileum. It often manifests as abdominal pain, diarrhea and weight loss, and may have mucus-pus-blood stool. Can use 5 aminosalicylic acid or prednisone and other glucocorticoid hormone class internal medicine treatment, internal medicine treatment is not feasible surgical treatment. 2. Ulcerative colitis: mostly manifested as abdominal pain, diarrhea, mucus, pus and blood stools, loss of appetite, etc., severe or active patients may appear wasting, anemia and other malnutrition manifestations. Glucocorticosteroids such as salazosulfapyridine and prednisone can be used for treatment, and surgery can be considered when it is ineffective. The use of drugs should be under the guidance of professional doctors. 3. Tumor: mostly seen in small intestine tumor and colorectal tumor and stomach cancer. Surgery is feasible. Please go to the hospital for examination and treatment as soon as possible when there is lethargy and blood in stool. Please follow the doctor’s instruction for medication.