Lactulose is an osmotic laxative, with laxative, hepatic encephalopathy treatment, but continuous consumption of lactulose for 10 years may also have certain harm, mainly including deterioration of efficacy, causing complications, body internal environment disorders: 1, deterioration of efficacy: continuous consumption of lactulose for 10 years will lead to the deterioration of efficacy at the same dose, with the development of time, the body needs the dose will gradually grow, aggravate the body’s load, easy to cause abdominal discomfort; 2, the body’s internal environment disorders: long-term use of lactulose, if diarrhea, etc., may lead to the body balance is disturbed, electrolyte disorders, endocrine disorders of the symptoms, the serious may cause low potassium, low sodium, low chlorine, etc., the plain need to pay attention to, if there is a significant diarrhea, it is recommended to suspend. Precautions when taking Lactulose, if the constipation symptoms do not improve or recur after a period of treatment, it is necessary to adjust the dose after consulting the doctor, or add other drugs with more moderate efficacy to alleviate drug resistance. In daily life need to pay attention to drink more water, eat more high-fiber vegetables, fruits, such as celery, spinach, bananas, apples, etc., appropriate exercise to promote intestinal peristalsis.