Creatinine 176μmol/L can be seen in physiological conditions such as strenuous exercise, acute renal failure such as diarrhea, etc., generally remove the causative factors, symptomatic treatment, can be improved without dialysis; pathological conditions can generally be stabilized for decades without dialysis, or may be a few years ranging from the need for dialysis, mainly based on the primary disease, the development of the disease and the degree of renal damage to judge. 1. Creatinine 176μmol/L can be seen in physiological conditions such as strenuous exercise, eating a lot of meat, etc., acute renal failure such as diarrhea, obstruction caused by, when, more rest and light diet, remove the cause of the disease and symptomatic treatment, return to normal, generally do not need dialysis. 2. Decades: The primary diseases leading to creatinine increase are polycystic kidney, chronic glomerulonephritis, acute renal failure, etc. The condition progresses slowly, and there are no complications such as infection, heart failure, edema, serious electrolyte disorder, etc. The proteinuria is less, and the control of blood pressure, glucose, and blood uric acid is stable, so it is possible to maintain decades of non-dialysis. 3. Several years: the primary disease is diabetic nephropathy, vasculitis kidney damage, lupus nephritis, focal segmental glomerulosclerosis, etc., the condition progresses rapidly, a large amount of proteinuria and hematuria can be seen, and the renal tissue damage is serious, the filtration rate decreases, the water and sodium retention, accompanied by intractable heart failure and serious electrolyte disorders, it may be a few years before the need to enter the dialysis treatment, to maintain life. Elevated creatinine must be timely to regular hospitals, under the guidance of doctors and active treatment to delay kidney damage.