Chronic liver failure conservative treatment can not be generalized, short patients can only survive for 1~2 years, long patients can survive for more than 10 years, the length of survival time and the severity of liver failure and other factors. Chronic liver failure is caused by hepatitis virus, alcohol, liver tumors, hepatobiliary diseases and other factors lead to chronic hepatic dysfunction, patients can be due to progressive decompensation of liver function, and then appear ascites, jaundice, portal hypertension, coagulation dysfunction, hepatic and renal syndrome, hepatic encephalopathy and other manifestations of the disease, the patient’s survival time is about 1 to 10 years, the length of time is related to the severity of the disease. Chronic liver failure can be evaluated using the MELD score, treated with drugs such as diammonium glycyrrhizinate and reduced glutathione; patients with hepatitis B virus infection can be treated with drugs such as entecavir and tenofovir; in addition, vitamin K and albumin supplementation are also needed. If the patient is suitable for liver transplantation, the patient can even get long-term survival after liver transplantation. If chronic liver failure is diagnosed, please follow the doctor’s instructions.