Advocate comprehensive treatment, including the following aspects: 1. Strictly control blood pressure, blood pressure target value should be maintained below 130/80mmHg. Patients with massive proteinuria should have their blood pressure controlled below 125/75mmHg. A combination of multiple antihypertensive drugs is usually required. The first choice of antihypertensive drugs is angiotensin-converting enzyme inhibitor (ACEI) or angiotensin II receptor blocker (ARB). ACEI drugs are commonly used: fosinopril, enalapril, pexipril, etc. ARB drugs are commonly used: Irbesartan, Coxsartan, Candesartan, Valsartan, etc. 2.Strict control of blood sugar. 3.Strict control of blood lipids. 4.Quit smoking.