In the treatment of cancer, there are often some adverse reactions, any of which will make the patients and their families suffer a lot and lose confidence in continuing the treatment. Pain is one of them. As radiotherapy and chemotherapy destroy tumor cells on a large scale, they also cause harm to normal body cells and damage positive qi, resulting in pain that affects the quality of life and even “death by pain”. According to statistics, there are about millions of people suffering from cancer pain every day in China, of which 30%~45% are moderate and severe pain. What kind of drugs should cancer patients choose when they are in pain? What are the misunderstandings in the treatment of cancer pain? Firstly, what are the dangers of pain? Patients with advanced cancer and other malignant tumors are usually accompanied by pain, and first of all, the pain obviously affects the quality of life of patients. Pain is a very painful psychological reaction, especially the strong persistent pain will make some patients “worse than death”, which obviously reduces the quality of life; secondly, pain is the direct cause of death of many patients. Pain is the direct cause of death in many patients. During pain, the pain receptors send nerve impulses through the afferent nerves to the central nervous system, which keeps the brainstem reticular formation and even the cerebral cortex in a state of excitation, so that the patient’s nerve cells are unable to rest with high quality and cannot sleep. Human beings can tolerate hunger, but they cannot tolerate not sleeping, and many patients with pain actually die of “pain” in the end. Improving the quality of life of cancer pain patients Under the premise of actively treating the primary disease, strengthening palliative measures is the most important measure to improve the quality of life of cancer patients. As a doctor, he/she must be people-oriented, even if the patient has only mild pain, he/she should not let the patient endure it, and he/she should not think that some cancer pain patients have low tolerance and mental problems. Patients should be allowed to cooperate with doctors and actively treat them. Drugs should be chosen as inexpensive as possible, so that patients with poorer financial conditions can also enjoy good pain relief. It is especially worth mentioning that the treatment of cancer pain should be carried out under the guidance of pain specialized doctors. Thirdly, there are misunderstandings in patients’ pain treatment Cancer pain not only restricts patients’ activities, reduces appetite and affects sleep, but also seriously affects patients’ quality of life. Now the problem is that some patients and their families wrongly “self-medicating” the treatment of pain, mainly focused on four aspects. 1, prefer to endure the pain rather than use morphine, for fear of “addiction”. Non-medical use of drugs for a period of time is called drug abuse, and tolerance and dependence can be formed after abuse. Patients with malignant tumors use medication under the guidance of a doctor for the treatment of pain, so it does not belong to addiction after drug abuse. As long as the medication is reasonable, the general speed of morphine and other opioid tolerance can be minimized. 2, Morphine Usage. Morphine injections can only be given subcutaneously, not intravenously or intramuscularly, because the latter two methods can form a rapid tolerance to morphine, which can quickly appear. Depending on the dosage form of morphine, the time of onset of effect after administration is different. Injections are the fastest, usually taking effect in about 10 to 30 minutes, immediate-release morphine takes effect within half an hour, and extended-release morphine takes two hours to take effect. The timing of administration must be designed according to the individual patient, choosing the most convenient time for the patient to take the medication orally. Morphine can also cause constipation and must be accompanied by a laxative. In addition to commonly used morphine, strong analgesics also have some new drugs come out, such as oxycodone extended-release tablets: the application of AroContin controlled-release technology, containing both immediate-release and extended-release parts to meet the need for rapid onset of clinical effects, and sustained strong effect, and at the same time, there are a variety of specifications (10mg/20mg/40mg), such as analgesic treatment of the “combination punch! “Oxycodone Oxycodone small file: for the laboratory semi-synthetic strong opioid drugs, has a high degree of bioavailability, small adverse reactions, both u, k receptor agonism, compared with the traditional morphine, fentanyl on neuropathic pain, visceral pass more advantageous. 3, after taking the drug still have pain, immediately change the drug. Initial use of the drug must master the dose and the time of use of the drug, morphine type after the formation of tolerance must increase the dose to achieve the effect of the initial use of the drug, can not easily think that the drug is ineffective, and at the same time, must be strictly in accordance with the time of the doctor’s prescription on the drug, to ensure that the blood concentration of the drug to reach the effective concentration. 4. Dulcolax is used for cancer pain. Due to the short duration of action of dulcolax (4 hours), the need for multiple doses, the required dose is large, the therapeutic effect is not accurate, secondary metabolite activity and other factors, it is no longer suitable for the treatment of cancer pain patients. What are the pain treatment methods? The treatment methods of cancer and other malignant tumors pain are: 1. Three-step drug therapy of World Health Organization. Mild pain can be treated with non-steroidal antipyretic and analgesic drugs, such as paracetamol, aspirin, anti-inflammatory pain, depo tablets, fenpropidone, etc.; moderate pain will be treated on the basis of the previous drugs with weak opioid drugs, such as codeine, dextropropoxyphene, etc.; low-dose strong opioid drugs, such as morphine, oxycodone, etc., can be used as well. Moderate pain uses strong opioids represented by morphine and oxycodone. 2, nerve block. According to the part where the pain is located, with local anesthetic drugs to continuously block the collection of pain signals sensory nerves can be exact analgesia, long-acting analgesic pump is designed according to this principle, it is the local anesthetic through the catheter continuously and evenly injected into the nerves that need to be blocked to produce analgesic effect. 3, biogenetic engineering. Cells that produce large amounts of endogenous opioid peptides (chromophobe cell lines) are transplanted into the patient’s subarachnoid space to produce opioid peptide analgesia. 4.Neurodestruction. In the past, radiofrequency ablation of the pituitary gland and subarachnoid destruction were used, which had a good analgesic effect but too many side effects, and is now seldom used.