Traffic accidents, violent incidents, falls, and sudden natural disasters in life can lead to craniofacial injuries in people. In the past 7 years, the average annual growth rate of the number of patients with craniofacial injury is 6.73%. Many patients with craniocerebral injury consult a lot of information before undergoing cranial repair, fearing rejection in case of skull repair after surgery. Currently, the repair material that patients hear most is titanium mesh, as the most widely used repair material, it has the advantages of firmness, forgeability, good cosmetic effect, and non-corrosiveness, but at the same time, there are many disadvantages. The titanium mesh material is not strong enough, but it is still prone to deformation after stress, and it can produce metallic artifacts, which can seriously affect the follow-up examination. From these perspectives, titanium mesh is not the best material for skull repair. The best material for cranial repair should be chosen for both patients who have had rejection after repair and those who have not yet had repair. The best material for cranial repair should be radiolucent, free of metallic artifacts, resistant to infection, non-conductive of heat and cold, free of any biological and physical changes, able to be precisely forged and shaped, and perfectly articulated with the defective area, which are all the characteristics that cranioplasty should have. With the progress of science and technology and clinical application research, the current polyether ether ketone material, commonly known as peek material, has been able to meet all the characteristics of the above ideal material and has been promoted in the clinical application, the patients with cranial defects repaired by this material have achieved good recovery, and no rejection reaction has occurred in the patients after surgery.