It is true that lentigo can be cured. Lentigo, also known as chronic granulocytic leukemia, belongs to one kind of chronic leukemia. In the past, it was mainly treated with interferon and hydroxyurea, which had a low cure rate, but with the introduction of tyrosine kinase inhibitors, the cure rate of lentigo was greatly improved, and it could reach more than 90%. Tyrosine kinase inhibitors include the first-generation product imatinib, the second-generation product nilotinib, dasatinib and so on. The introduction of tyrosine kinase inhibitors, although greatly improved the cure rate of lentigo, but the cure rate still can not reach 100%, clinically there are a small number of patients who receive tyrosine kinase inhibitor treatment is ineffective, drug-resistant, the most evolution into the accelerated stage, the rapid change of the stage, this part of the patient needs to carry out allogeneic hematopoietic stem cell transplantation, in order to achieve the possibility of a cure. Specific drug use and treatment should be carried out under the guidance of a physician.