Many people have heard of Botox and know that Botox has powerful wrinkle-reducing functions, removes the signs of age and rejuvenates the beautiful face, which is a non-invasive cosmetic magic that is popular all over the world. But do you know the use of Botox in the treatment of strabismus? Botulinum toxin is a bacterial exotoxin produced by Clostridium botulinum during the growth and reproduction process, and is divided into seven types: A, B, C, D, E, F and G. The structure and function of type A has been improved over that of type G. The structure and function of type A is well understood and was first used in clinical practice. Dr. Alan Scott of the Smith-Kettlewell Eye Institute in San Francisco, USA, who first applied botulinum toxin in clinical practice, collaborated with Edwara Schantz, a world-renowned botulinum toxin expert, and began to demonstrate in 1973 that botulinum toxin type A (BTXA) could help correct strabismus through animal testing, and reported in 1980 that it had been successfully tried on patients with strabismus. The results of the treatment were reported in 1980. The injection of BTXA into the muscle belly of the extraocular muscle causes a temporary paralysis of the injected muscle and a decrease in muscle tone, while the tension of its antagonist is relatively increased, bringing the strength of the pair of antagonist muscles into balance again to correct the eye position. Currently, BTXA is mainly used in ophthalmology for patients with newly developed abducens nerve palsy, limited eye movement due to trauma or surgical injury to a particular extraocular muscle, restrictive strabismus due to thyroid-related eye disease, and patients with sudden onset of infantile strabismus of unknown origin. In order to prevent contracture and fibrosis of the extraocular muscles that are antagonistic to the paralyzed muscles, protect the patient’s binocular vision, improve compensatory head position, and eliminate diplopia. Therefore, the use of botulinum toxin to treat strabismus at an early stage of its onset is an effective treatment to help patients recover early and improve their quality of life. Botox acts on the neuromuscular junction and inhibits the release of presynaptic neuromediators (acetylcholine). The course of action takes about 3 months and can be repeated in due course. Repeated injections of botulinum toxin have no allergic reactions and no long-term ocular or systemic side effects.