New quadruple therapy mainly refers to the combination of antibiotics with proton pump inhibitors, gastric wall mucosal protective agents for drug treatment, new quadruple therapy in clinical practice is mainly applicable to patients with H. pylori infection. The combination of antibiotics refers to the selection of two symptomatic antibiotic drugs for anti-H. pylori treatment, commonly used types of drugs are metronidazole, clarithromycin, furacilin, etc. Proton pump inhibitors mainly include types of omeprazole, rabeprazole, esomeprazole, etc. This type of drugs can prevent excessive gastric acid by inhibiting the secretion function of acid-secreting glandular wall cells, and relieve patients of gastric distension, acid reflux, heartburn and other adverse This type of drug can prevent excessive gastric acid by inhibiting the secretion function of acid-producing glandular wall cells, and relieve the patient’s adverse symptoms such as gastric distension, acid reflux and heartburn. Gastric mucosal protective agents can form a protective layer on the superficial mucosa of the gastric wall to reduce gastric acid irritation and accelerate the healing and repair of damaged tissues, such as gastrin, teprenone, aluminum sulfate, etc.