Coxsackieviruses can cause four types of illnesses, including myocarditis, encephalitis, secondary bacterial infections, and meningitis. The incubation period of coxsackievirus is 1-3 days, and the onset of illness is characterized by upper respiratory tract infections, fever, runny nose, and in some people, loss of appetite and herpes. Coxsackie virus can be accurately detected by serologic tests or virus isolation methods, with the most prominent method being the virus isolation method, which has a higher accuracy rate. Prevention of Coxsackie virus is important, must control the source of infection as well as cut off the transmission pathway, for susceptible people to be protected, can be carried out injection of gammaglobulin to prevent infection, according to the different causes of the disease for treatment, usually using ribavirin or interferon. In the case of meningitis caused by Coxsackie virus, a small number of people recover with sequelae.