Rheumatoid arthritis patients taking celecoxib capsules after face swelling may be celecoxib adverse drug reaction, but face swelling this symptom may also be renal insufficiency, hypothyroidism and other causes. 1. Adverse drug reactions: celecoxib is a selective inhibition of cyclooxygenase-2 to play an anti-inflammatory, analgesic effect of non-steroidal anti-inflammatory drugs, the drug may be adverse reactions, including heart failure, and facial edema is one of the clinical symptoms of heart failure. 2. Renal insufficiency: after the patient’s glomeruli are severely damaged by various factors such as drugs and diseases, due to the disturbance of acid-base balance, water-electrolyte balance and excretion of metabolites, the patient may suffer from facial edema, fatigue, and urinary symptoms. 3. Hypothyroidism: when there is thyroid hormone resistance or insufficient thyroid hormone secretion in the patient’s body, there will be mucous edema, which is mainly manifested as facial edema, thickening of the nose and lips, and dull expression and other symptoms. Rheumatoid arthritis patients taking celecoxib capsules after the symptoms of facial edema may have other reasons, it is recommended that patients to the regular hospital rheumatology and immunology department and other related departments to further clarify the specific causes.