Schegren’s syndrome, also known as dry syndrome, is a systemic autoimmune disease characterized by chronic inflammation and progressive dysfunction of the lacrimal and salivary glands. Schegren’s syndrome can be divided into primary and secondary, with primary Schegren’s syndrome referring to those whose lesions are confined to the exocrine glands themselves and secondary Schegren’s syndrome referring to those with other autoimmune diseases. It is a highly autogenous disease, meaning that the patient’s immune system produces antibodies to destroy its own tissues, with the salivary and lacrimal glands often being the first to be attacked. In normal people with Schegren’s syndrome, symptoms such as tooth loss, fungal infection and corneal abrasion are likely to occur, making even simple drinking movements inoperable. Some patients experience swelling of the cheeks, slight pressure pain with salivary secretion, and palpable lumps that can be easily misdiagnosed as tumors. The disease mostly occurs in middle-aged women, with dry mouth and eyes as the main symptom in the early stage, and a few patients show non-specific symptoms such as fatigue and weakness, and the disease starts insidiously and progresses slowly, so it is not easy to attract patients’ attention. Therefore, it is important to consult the doctor promptly to avoid delaying the disease.