Hypertension can not be lowered by taking medication, commonly due to improper use of drugs, hypertension triggers are not removed, secondary hypertension. 1. Inappropriate use of drugs. Insufficient dosage, small dosage, no combination of drugs, or poor patient compliance, often missed doses. Lowering blood pressure needs a process, it may be one kind of drug at the beginning, if the blood pressure can’t be lowered, it may be combined with other drugs, such as using one, two, or three drugs at the same time. 2. Hypertension triggers are not removed. For example, the patient’s long-term mental tension, stress, depression, too much salt, smoking, alcoholism, overweight can be caused by taking medication does not come down. 3. Secondary hypertension. If the patient has used 3~4 antihypertensive drugs, and still can not control the blood pressure within a reasonable range, it is necessary to consider secondary hypertension such as renal vascular stenosis, pheochromocytoma, primary aldosteronism, and so on. At this point, it is necessary to treat the primary disease in order to effectively reduce blood pressure. If there is high blood pressure can not be lowered by medication, it is necessary to consult a doctor in a timely manner to identify the cause of the disease, and symptomatic treatment.