Delange syndrome refers to multiple congenital dysplasia syndrome, a rare condition. The mode of inheritance is autosomal dominant and involves multiple organ systems, mostly de novo mutations. Currently, there is no specific treatment, and prevention is the mainstay. A more effective means of prevention is premarital medical examination. Common organ abnormalities include hearing loss, pyloric stenosis, hypospadias, cryptorchidism, congenital diaphragmatic hernia, epilepsy, myopia, and ventricular septal defects. Most patients also have severe mental retardation. Because Dran Fever Syndrome causes abnormalities in multiple systems, it is important to follow medical advice and choose a targeted treatment plan that is right for you. For patients who have been diagnosed, it is important to keep abreast of the abnormalities in the organs being evaluated and to treat the abnormal organs to mitigate the progression of the disease.