Painful breast nodules are not related to the severity. Breast nodules can be seen in, for example, cystic hyperplasia of the breast, fibroadenoma of the breast, breast cancer, and so on. 1. Breast cystic hyperplasia: it is a disease mainly related to the imbalance of estrogen and progesterone, and is often found in the physical examination of the breast with painful nodules, unclear boundary, and may be accompanied by nipple overflow. The treatment for this disease is mainly symptomatic, such as the use of Tamoxifen and other drugs. 2. Breast fibroadenoma: It is a fibroblastic tumor in the lobules of the breast, manifested as a painless lump, which is hard, like a leather ball, smooth and easy to push, and can be cured by surgical excision. 3. Breast cancer: it is a malignant tumor with various types, and the prognosis of triple-negative breast cancer and inflammatory breast cancer is poor. Common clinical manifestations include breast nodule orange peel sign, dimple sign, etc. Usually there is no pain in the early stage, and pain symptoms may appear in the late stage. The main treatments include surgery, chemotherapy and radiation therapy. It is recommended that when breast nodules are found, one should consult a regular hospital in time, and standardize the treatment under the guidance of a doctor after a clear diagnosis is made.