Drugs for the treatment of recalcitrant heart failure include positive inotropic agents or diuretics, and neuroendocrine inhibitors or vasodilators can also be applied, all of which can treat recalcitrant heart failure. Recalcitrant heart failure is dominated by recurrent episodes of heart failure, in the course of heart failure, other drugs such as cardiotonic agents, diuretics, asthma medications, can be applied to the treatment of recalcitrant heart failure, but for recalcitrant heart failure treatment of specific drugs, for example, can be applied to the application of neuroendocrine inhibitors, such as patients can be applied to the application of drugs in the class of ACEIs, ARBs, and the patient should also be Intravenous injection of positive inotropic agents, such as dobutamine and milrinone. In addition, patients can also apply vasodilators, such as sodium nitroprusside, nitroglycerin, can be used in the treatment of intractable heart failure.