Four Substances Soup can be used to treat facial colorlessness caused by deficiency of blood in the body, but it is not recommended to use Four Substances Soup for skin problems caused by other reasons. There is no definite time for how long Four Substances Soup should be consumed to make the skin better, and it is related to individual constitution and other factors, which vary from person to person, so it is necessary to follow the doctor’s instructions to use the medication. Four Substance Soup is composed of Angelica sinensis, Radix Rehmanniae Praeparata, Rhizoma Ligustici Chuanxiong and Radix Paeoniae Alba, which can tonify and regulate blood, and is used to treat facial colorlessness, insomnia and palpitations (rapid heartbeat, often accompanied by panic), pale lips and nails, and women with low menstrual flow and menstrual closure caused by deficiency of blood in the camp and the blood (deficiency of blood in the body). The adverse effects of this formula are not clear, and Four Substances Tang is not suitable for cases of yin deficiency and fever, as well as for cases of blood collapse and qi detachment. Therefore, Four Substances Tang can improve the lusterless skin caused by deficiency of Ying and Blood. However, there is no clear time for the onset of effect, which is affected by the degree of illness, individual constitution and other factors, there are individual differences, and the medicine should be used under the guidance of doctor’s diagnosis.