Colon cancer undergoing chemotherapy for 6 times with good spirit cannot assess the prognosis of patients, it can only show that patients can tolerate the side effects of chemotherapy and have a better quality of life, but it cannot be used to assess the treatment effect. Colon cancer is a common malignant tumor in clinic, and chemotherapy is a common treatment method for this disease, which will affect patients’ appetite, mental state and bone marrow hematopoiesis to a certain extent. If the patient can keep good mental state during chemotherapy, it suggests that the patient is in good physical condition and can tolerate the side effects of chemotherapy better, but it does not assess the efficacy of the treatment. Therefore, although retaining a good mental status after chemotherapy does not assess the prognosis of the patient, having a good quality of life is a good sign.