The composition of Radix Rehmanniae Pill and Xiangsha Liujun Pill contains contraindications for pairing, therefore Radix Rehmanniae Pill and Xiangsha Liujun Pill are not recommended to be taken together. Radix Rehmanniae Pills is composed of Radix Rehmanniae Praeparata, Rhizoma Atractylodis Macrocephalae, Radix et Rhizoma Atractylodis Macrocephalae, Radix et Rhizoma Glycyrrhizae, Radix et Rhizoma Glycyrrhizae. Its efficacy is to warm the middle and strengthen the spleen. It can be used for nausea and vomiting due to deficiency and coldness of the spleen and stomach (spleen and stomach weak and cold), cold pain in the epigastric region (stomach and epigastric region and abdomen feel cold and painful), and lack of warmth in the hands and feet. Adverse effects and contraindications of Radix Rehmanniae Pills are not known. Xiangsha Liujun Pill is composed of sand nuts, codonopsis, poria, roasted licorice, fried atractylodes, wood sorrel, and prepared semixia. The effects are to benefit qi and strengthen the spleen (regulating the qi of the spleen and stomach), and harmonize the stomach. It is indicated for spleen deficiency and qi stagnation, distension and fullness of the epigastrium (abdomen), belching (hiccup), lack of appetite, and loose stools. The adverse reactions and contraindications of Xiangsha Liujun Pill are unclear Radix Rehmanniae Pills and Xiangsha Liujun Pills contain Radix Rehmanniae Praeparata and Radix et Rhizoma Pinelliae respectively, which are contraindicated, therefore, it is not recommended to take them together. The combination of drugs should be used under the guidance of a doctor, do not blindly self-medication.