Bone Marrow Picture Alteration is a phenomenon that refers to the changes in the degree of bone marrow cell proliferation, bone marrow cell count, granulocyte-red ratio, and the ratio of hematopoietic cells in each system and stage of hematopoiesis. The following is an example of leukemia to introduce what are the prevention methods of bone marrow image changes? 1, spiritual care medical personnel and family members should make the patient’s mood stable, overcome the pessimism and despair of the disease, encourage the patient to actively fight against the disease, and well cooperate with the treatment. 2, pay attention to the patient to rest well, especially in the unstable condition of the treatment period, reduce or avoid visiting, avoid going to public places. 3.Oral and perianal cleaning and nursing Supervise the patients to gargle daily with saline, hydrogen peroxide, furacilin containing mouthwash or scutellariae and silver flower decoction to prevent oral infections; keep the urine and feces unobstructed, pay attention to cleanliness and hygiene, and prevent skin and mucosal infections, and wash the perianal area with decoction of septoria, dandelion, and so on. 4.Nutritional diet To allow patients to eat nutritious, tasty food, intake of vitamins, protein-rich foods such as fresh vegetables, fish, eggs, poultry, meat, turtle, etc. Avoid eating spicy products, such as green onions, peppers and so on. 5.Encourage patients to drink more water, eat fresh fruit, avoid smoking and alcohol. 6, indoor air should be kept fresh, the ground should be clean and disinfected.