The antihypertensive drugs with good antihypertensive effect and few side effects should be analyzed in the context of the patient’s specific clinical situation: First, young people with hypertension manifest as increased sympathetic excitability accompanied by increased heart rate, the best antihypertensive drug in this case is a beta-blocker, such as metoprolol extended-release tablets, bisoprolol, carvedilol, etc. Second, middle-aged people with hypertension are often accompanied by increased peripheral vascular resistance, the best antihypertensive drug in this case is a calcium antagonist, such as nifedipine controlled-release tablets, amlodipine, etc. Third, for the elderly, antihypertensive drugs can choose calcium antagonists and diuretics, such as amlodipine, hydrochlorothiazide, etc. Fourthly, women who are preparing for pregnancy and pregnant. This special group of people can consider choosing calcium antagonists according to the specific situation, such as amlodipine besylate, etc. The effect is better and the side effects are relatively small. Fifth, for example, women during pregnancy, can not choose ACEI class, ARB class antihypertensive drugs at the same time also pay attention to the application of beta-blockers, because the class of drugs can affect the development of the fetus.