Parkinson’s disease is a chronic progressive, disabling disease of the middle-aged and elderly, once the disease, its quality of life continues to decline, the body is stiff as shackles plus body, limbs trembling anxiety, depressed mood pessimistic disappointment, sleepless nights suffering. Patients have tried a variety of drugs, but with little success, daily life has become more and more difficult, in the end how should be treated? Most patients are confused. Experts believe that for Parkinson’s disease, the principle of staged treatment should be adopted. In the first few years of the disease, patients are in the “honeymoon period” of drugs, when you can use regular drug therapy, supplemented by physical rehabilitation exercises and psychological guidance, so as to slow down the rapid progress of Parkinson’s disease. With the prolongation of the disease, the efficacy of oral medication will gradually decline; even if the amount of medication is increased, the effect is not significantly improved, but the side effects of medication are more serious, causing switch phenomenon, anomia, hallucinations, anxiety, depression, sleep disorders, lower limb edema, and even abdominal distension, constipation, etc. At this point, patients don’t know what to do! Start asking around for new treatments, and even misbelieve and misuse folk remedies, often with very little success or counterproductive; they do not know to go to a regular hospital to see the doctor, not to mention that Parkinson’s disease can also be treated surgically! When it comes to surgery, many patients may worry and fear that the surgery will hurt their brain. In fact, neuromodulation surgery is the most precise, minimally invasive, safe and effective surgery in neurosurgery. It is believed that the onset of Parkinson’s is related to the insufficient secretion of dopamine and relatively high secretion of acetylcholine in the brain; neuromodulation surgery can rebuild the balance of the above neurotransmitters and inhibit the overexcitation of cholinergic nerves, thus treating Parkinson’s disease. The characteristics of this minimally invasive surgery are: 1. Accurate positioning: using multi-dimensional image CT/MRI/DTI fusion positioning technology, the nucleus can be precisely positioned, and the calculation error is only 0.01 mm. 2. The patient is always awake and maintains verbal communication with the surgeon during the operation 4. Effectiveness: patients who participate in the operation will have different degrees of symptomatic improvement. In conclusion, experts believe that for Parkinson’s patients who have passed the “honeymoon period” of medication, they can try minimally invasive surgery if their physical condition allows it (no serious physical disease). This surgery can help reduce the pain of the disease and improve the quality of life of the patient. Of course, even if there are indications for surgery, doctors will conduct detailed preoperative examinations and assessments, and provide adequate preoperative preparation and psychological guidance, which are key to ensuring the success of the surgery.