Clotrimazole cream should not be used to treat perianal eczema. It can be used if perianal eczema has a secondary fungal infection. Clotrimazole cream is an antifungal drug, mainly used for fungal infections caused by ringworm, tinea corporis, tinea pedis, tinea capitis, as well as Candida onychomycosis and Candida vulvovaginitis and other diseases. Adverse reactions are local irritation, erythema, itching, etc.; contraindications are not clear. Perianal eczema is due to a variety of factors stimulation caused by local inflammatory reaction, does not belong to the fungal infection, so clotrimazole cream can not be used to treat perianal eczema. If perianal eczema has secondary fungal infection can be used. For the treatment of perianal eczema, topical glucocorticoid drugs (mometasone furoate cream, dexamethasone ointment), or with the calcium-modulated neural phosphatase inhibitors (tacrolimus cream, pimecrolimus cream) and other drugs. Diseases of the skin should go to the hospital for examination in time, and all medications need to be used under the guidance of a professional doctor to avoid abusing medications by yourself.