Large bumps on the body are itchy with the following possibilities: 1. Drug dermatitis caused by drug allergy. It can appear a large edematous erythema around the body, accompanied by itching, some of the erythema can be seen on blisters or large blisters and other conditions. It is necessary to sedate compound glycyrrhizic acid monoammonium S sodium chloride injection 200ml once daily, combined with oral loratadine citrate capsule, with oral levocetirizine hydrochloride capsule, to strengthen the anti-allergic, anti-itch effect, and at the same time can be treated with topical application of dextran ointment. 2, bacterial infection or viral infection, but also may be serious medical diseases, such as renal failure, or allergic phenomenon appearing urticaria, can be in A large area of wind masses, wind bumps around the body, the rash can disappear quickly, but can quickly return, accompanied by intense itching. It can be treated with oral Avastin capsules and topical glyburide lotion.