Gallstones can not be applied ursodeoxycholic acid, may be related to contraindications to the use of the drug, adverse reactions and stone type. 1. Contraindications: ursodeoxycholic acid should be prohibited in patients with complete intestinal obstruction and severe hepatic hypoplasia. If there are such contraindications to the use of ursodeoxycholic acid, this drug can not be applied. 2. Adverse reactions: after the use of the drug, some patients may experience constipation, headache, pancreatitis and tachycardia and other adverse reactions. Patients who clearly have adverse reactions after using the drug should not apply this drug. 3. Stone type: This product is suitable for cholesterol stones, and has no dissolving effect on mixed stones and bile pigment stones, which should also not be applied. The patient’s condition and physical condition are different, the corresponding medication, must be confirmed after diagnosis, follow the doctor’s instructions, do not use the drug arbitrarily.