It is normal to go to the toilet once in the middle of the night. Under normal circumstances, the frequency of urination at night is 0-1 times, and as long as it is not more than once, it is normal. It is mostly related to factors such as drinking more water or drinks containing sugar or too much water in food at night while sleeping, and is not a disease condition. If you get up more often than once, for more than 3 months, you may have a related disease and need to go to the hospital for further examination, such as to rule out urinary tract infections, prostatitis, or kidney disease, resulting in concentration and dilution dysfunction. It is also possible to suffer from other diseases such as diabetes mellitus, glomerulonephritis, or cardiovascular diseases that lead to heart failure and frequent urination at night. However, as long as it is within one time, it is normal and does not require any treatment or examination.