Very severe headaches can be a precursor to a serious illness. There is also the possibility of other disorders associated with headaches, which may be caused by psychosomatic factors, cranial lesions, extracranial lesions, and systemic diseases. 1. Subarachnoid hemorrhage: Bursting headaches may occur when an intracranial aneurysm ruptures and bleeds, and may be life-threatening. 2. Hypertensive crisis: severe headache may occur when the blood pressure rises sharply, and the blood pressure measurement suggests that the systolic blood pressure is more than 180mmHg and the diastolic blood pressure is more than 120mmHg accompanied by nausea and vomiting. 3. Craniocerebral lesions: if the patient has meningitis, cerebral hemorrhage, intracranial metastases, cerebral contusion, etc., it will lead to head pain. 4. Extracranial lesions: when the patient has skull fracture, cervical spondylosis and other neck diseases, trigeminal nerve and occipital neuralgia, etc., it will lead to headache symptoms. 5. Systemic diseases: if the patient is affected by influenza, alcohol, drugs and other factors, thus causing headaches. 6. Psychosomatic factors: when the patient has psychosomatic factors, such as depression, anxiety, neurasthenia, etc. can cause headaches. It is recommended that patients go to the regular hospital in a timely manner, under the guidance of the doctor, the relevant examination, according to the results of the examination, to take targeted treatment.