When a small vesicle suddenly appears on a woman’s labia majora, it is necessary to determine the specific nature of the vesicle based on the specific form of the vesicle and the accompanying symptoms. If there is no redness or swelling on the surface of the vesicle and there is no pain, and if the vesicle is found to be under the skin of the labia majora with a certain sliding sensation when touched, it should be considered to be caused by a simple subcutaneous cyst. If the vesicles are relatively small, they can be left untreated for the time being. If the vesicles of the labia majora are harder to touch, and there are obvious symptoms of redness and pain, it should be considered that they may be caused by vulvar boils, which will all become pus at a later stage, and erythromycin ointment can be used topically. If a woman’s labia majora vesicles are not obviously red, swollen and hard to the touch, but there is a stinging phenomenon, consider that it may be a blister caused by genital herpes virus infection, after the rupture of the blister will cause ulcers appear, and the pain is serious, antiviral treatment should be performed.