Elevated free thyroxine and lowered thyrotropin after total resection of thyroid cancer are considered to be hyperthyroidism, and common symptoms include weight loss, excessive sweating, and hyperphagia, which can be treated with medication as prescribed by the doctor. Elevated free thyroxine and lowered thyrotropin after total resection of thyroid cancer are abnormal phenomena, and hyperthyroidism is considered. Postoperative hyperthyroidism may be related to autoimmune abnormalities and postoperative thyroxine tablets. Hyperthyroidism can cause patients to experience weight loss, excessive sweating, hyperphagia, thermophobia, and agitation. For those who are diagnosed with hyperthyroidism, they can be treated with antithyroid drugs such as methimazole and propylthiouracil and beta-blockers such as propranolol and metoprolol as prescribed by the doctor. Patients need to closely observe the condition during treatment so as to adjust the treatment program according to the change of condition. It is suggested that those who have elevated free thyroxine and lowered thyrotropin after total resection of thyroid cancer should undergo further detailed examination, and follow the doctor’s instructions to use medication after clarifying the disease, and should not use medication indiscriminately on their own.