Rheumatic disease should be based on clinical symptoms and signs of the prompting, choose the appropriate examination, such as blood tests, imaging tests, pathology examination. 1. Clinical symptoms and signs: for example, diffuse connective tissue disease often has fever, arthralgia, rash and muscle pain; rheumatoid arthritis patients have morning stiffness, swelling and tenderness in joints; ankylosing spondylitis can be manifested as limitation of spinal movement, pain in sacroiliac joints and tendon ends, etc. 2. Blood test: Diffuse connective tissue disease can be positive for anti-nuclear antibody and (or) autoantibodies; rheumatoid arthritis can be positive for rheumatoid factor, blood sedimentation, C-reactive protein and anti-cyclic citrullinated peptide; anti-streptococcal hemolysin O can be elevated in the blood test for rheumatic fever; and elevated blood uric acid can be seen in gout or hyperuricemia. 3. Imaging examination: seronegative spondyloarthropathies can have X-ray of sacroiliac arthritis, joint X-ray of patients with rheumatoid arthritis can see bone destruction and joint deformity. X-ray examination is more meaningful to the diagnosis of osteoarthropathies, and for the absence of obvious abnormality in X-ray, CT, MRI, dual source CT and other examinations can be chosen. 4. Pathological examination: diffuse connective tissue disease histopathological biopsy can be seen mucus-like edema, fibrin-like degeneration, vasculitis, lymphocyte or plasma cell infiltration and other manifestations; rheumatoid arthritis pathology is mainly manifested as joint synovial inflammation, vascular cataract formation and erosion. Rheumatic diseases are more, and the etiology is complex, it is recommended to consult a doctor in a timely manner, under the guidance of a professional doctor to improve the examination, a clear diagnosis.