Does ibuprofen cause increased histamine

Ibuprofen belongs to the non-steroidal anti-inflammatory drugs, can inhibit the production of inflammatory mediators prostaglandins, play the role of antipyretic and analgesic, and does not cause an increase in histamine. Ibuprofen is mainly used for the relief of mild to moderate pain such as headache, migraine, toothache, etc. It can also be used for fever caused by colds. It does not cause an increase in histamine and inhibits the production of prostaglandins by inhibiting the enzyme cyclooxygenase. Prostaglandins are strong inflammatory mediators that dilate blood vessels and cause fever. The adverse reactions of this product include nausea, vomiting, dyspepsia, dizziness, headache, tinnitus, etc. It is contraindicated for those who are allergic to NSAIDs, pregnant women and lactating women. Please use the drug under the guidance of a physician, and should not be used blindly.