Mycoplasma urealyticum infection is a sexually transmitted disease. Mycoplasma urealyticum can be transmitted through sexual intercourse and is one of the important pathogens of sexually transmitted diseases. Mycoplasma urealyticum is the smallest prokaryotic organism between bacteria and viruses and is found mainly in the human genitourinary tract. The main mode of transmission of Mycoplasma urealyticum is direct sexual contact, but it can also be transmitted through contaminated clothing and indirect contact. After infection with Mycoplasma solani, patients are treated mainly with antibiotics, and the drugs commonly used in clinical practice are tetracyclines, macrolides and quinolones, among which tetracycline antibiotics are preferred. In daily life, patients should avoid unclean sex and do not share personal items with others. When Mycoplasma solium infection occurs, patients should go to the urology department of the hospital in time to get a clear diagnosis and targeted treatment.