Esophagectomy should be esophagectomy for esophageal cancer, and esophagectomy for esophageal cancer has no effect on voice in general, but if the recurrent laryngeal nerve is damaged during the operation, it will have effect on voice. Esophageal cancer is a malignant tumor originated from the mucosal epithelium of the esophagus, which mainly manifests in symptoms such as difficulty in swallowing, reflux and pain. If there is no compression to the recurrent laryngeal nerve, esophagectomy for esophageal cancer has no effect on voice. However, if the lymphatic tract metastasis of esophageal cancer leads to enlarged supraclavicular lymph nodes, which may compress the recurrent laryngeal nerve and damage the recurrent laryngeal nerve during the operation, then the voice will be affected. The causes of esophageal cancer are complicated, mostly related to diet, living habits, precancerous diseases, heredity, infection and other factors. It is recommended that patients who undergo esophageal cancer resection should go to regular hospitals for the operation and make reasonable and effective plans before the operation, so as to avoid affecting the vocalization of the throat.