Colorectal cancer liver metastasis (CRLM) is a difficult problem in the treatment of colorectal cancer and its most important cause of death. Surgical resection is the most effective means to eradicate CRLM, with a 5-year survival rate of 23% to 58% after surgery. However, unfortunately, 80% to 90% of CRLM cannot be surgically resected at the initial evaluation. In the last decade, local treatments such as RFA have been applied experimentally in the comprehensive treatment of CRLM, and promising clinical results have been achieved. The author summarizes the recent literature, the application of RFA in the comprehensive treatment of CRLM is mainly in the following three aspects. First, the treatment of CRLM that cannot be surgically resected, including cases where the tumor is adjacent to large intrahepatic vessels, insufficient residual liver volume after surgery, many systemic comorbidities, combined extrahepatic metastases or refusal of surgical resection. An RCT study showed that the efficacy of RFA-adjuvant systemic chemotherapy for inoperable CRLM was significantly better than that of palliative chemotherapy alone. Secondly, RFA-assisted surgical resection for CRLM is increasingly used in the treatment of multiple CRLM lesions involving both the right and left hemispheres, where the larger lesions can be surgically resected and the smaller lesions can be treated with RFA, which can also reduce the risk of surgery and avoid excessive resection of the normal liver, while ensuring the efficacy of surgery. Thirdly, laparoscopic radical resection of colorectal cancer combined with RFA for the treatment of colorectal cancer combined with concurrent CRLM. CRLM found at the same time as the diagnosis of colorectal cancer is difficult to treat because it involves both colorectal and liver cancer foci, and there is a lack of clinical studies of large cases, so the treatment strategy is still controversial. Traditionally, the primary colorectal cancer is resected first, and then CRLM is resected in stages after 12-16 weeks. with the elevated status of RFA treatment in the comprehensive treatment of CRLM, the efficacy of RFA for resectable CRLM has been widely recognized, and laparoscopic radical colorectal cancer combined with RFA for colorectal cancer with concurrent CRLM has become a possible treatment option.